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What’s Alterna™
Alterna™ | Botanical Nicotine Alternative is a proprietary blend of botanical extracts that combine to
deliver full spectrum support for moving away from nicotine while continuing to enjoy vaping.
Our proprietary blend delivers two gentle stimulants plus support for anxiety, stress, appetite and detox.
All the things necessary to help someone kick the addiction to nicotine. Alterna is designed to mimic
nicotine effects without impacting dopamine levels.
Alterna can be used in eliquids - providing consumers an effective alternative to Nicotine and full spectrum
support for nicotine withdrawal. It provides juice brands an alternative to becoming a tobacco company
and shops and DIYers a non toxic ingredient for house brands and hobbies.
The blend can also be used as a general purpose ingredient for non smoker and non nicotine users who
want more energy, less anxiety, appetite control and detoxification - providing manufacturers a bridge to
the broader application of vaping to mainstream wellness.
The well studied effects delivered by the herbal extracts we choose are documented in the pharmacopeia
of botanical ingredients and have been studied for thousands of years in both ancient and modern
medical practices.
Alterna™ Description
The botanicals in Alterna combine to provide two gentle stimulants plus support for anxiety, stress,
appetite and detox. We encourage you to research the ingredients we use in our proprietary blend and
sample the product so you can experience the effect for yourself.
PROPRIETARY BLEND :Green Tea, Mate, St. John's Wort, Passion flower, Burdock Root, VG, Deionized Water
EFFECTSPeople generally experience a gentle stimulant effect offset by calming herbs then notice the appetite
control and detox effect.
BENEFICIAL EFFECTSBased on the known properties of the well studied herbal extracts we use, Alterna has the following
physiological effects: Stimulant, Calming, Antioxidant, Anti-inflammatory, Detoxifying (Blood/Organs)
PROPERTIESContains - Xanthenes, Polyphenols, Natural MAOIs (anti-anxiety), Antioxidants, Vitamin C, Vitamin E,
Potassium, Magnesium
Value Proposition
“Better with Alterna™”
After a week or two of Alterna use, customers report that the "Alterna Effect" is better than what's
delivered by nicotine eLiquids.
Alterna™ addresses the physiological effects that many people desire on a daily basis - energy boost, mood
support and detoxification. And, unlike nicotine eLiquids, the proprietary blend offers more than just a
stimulant.
The botanicals in Alterna deliver calming extracts that enable the user to really benefit from the energy
boost without getting jittery, anxious or suffering other side effects of nicotine. There are two additional
extracts that are known to assist detoxification - helping the body clear toxins from the blood and organs.
And, we are all aware of the negative side effects of nicotine. Even if many want to deny them. The fact
that Alterna provides the support it does without affecting dopamine levels is truly amazing.
Again, a full spectrum solution for consumers who want to move away from nicotine and continue
vaping for the long term.
Alterna™ | LEGAL & TAXESWhat is the regulatory and taxation landscape surrounding Alterna™?
● We believe it will be very difficult to classify Alterna-based vaporization liquids as tobacco products
as we do not fall under the guidelines for an ENDS.
● CA BOE has stated that our products do not fall under Prop 56 and are not subject to tobacco
Taxes
● Extracts are all recognized as herbal supplements by the FDA under the Dietary Supplement Health
and Education Act (DSHEA)
● The FDA has said they will evaluate non-nicotine eLiquids on a case by case basis
● We are not a registered tobacco company and do not sell nicotine products
● Ideally, we’ll be classified as an herbal supplement or aroma product with no “sin” taxes
● FDA could come and have us register as an OTC Botanical Drug with cost being far less that those
for new tobacco product
● To have the product removed from the market the FDA has to prove it is harmful and we have
been delivering these products for over two years with no reports of adverse reactions
● We'll follow FDA guidelines for marketing herbal supplements
● The FDA could look favorably upon a product that weens people off of nicotine
The Science Behind Alterna™Prescription for Herbal Healing
A lot of our research and learning has come from “Prescription for Herbal Healing”, the definitive source
for choosing the optimal herbal therapy. From Phyllis A. Balch, the trusted name in natural healing and
Stacey Bell who consulted the largest and most authoritative American and European sources and
databases to ensure up-to-date scientific information on safety and efficacy.
It includes Information on more than 200 herbs and herbal blends ranging from well-known items, such as
ginseng and St. John's Wort, to less familiar remedies as well as Chinese and ayurvedic herbal
combinations.
books.google.com/books/about/Prescription_for_Herbal_Healing.html?id=xSyXZwEACAAJ&hl=enChinese Herbal MedicineA medicine system developed in China more than five thousand years ago, the herbs used in Alterna are
well studied to say the least.
For centuries, doctors have compiled detailed information about the pharmacopoeia and placed great
emphasis on the protection of the patient. Adverse reactions can occur with any form of medicine.
However, in the case of herbal medicine these adverse reactions are rare.
According to the Institute for Traditional Medicine, “more than three hundred herbs that are commonly
used today have a history of use that goes back at least 2,000 years. Over that time, a vast amount of
experience has been gained that has gone towards perfecting their clinical application.”
www.itmonline.org/According to Chinese clinical studies, these herbs that have been added to the list of useful items over the
centuries, can greatly increase the effectiveness of modern drug treatments, reduce their side-effects, and
sometimes replace them completely.
In this case we believe they can effectively replace nicotine and provide lasting benefits that keep vapers
engaged long after they stop smoking and without selling them an addictive, sometimes toxic substance.
Vaporization
When used properly, personal vaporizers, ultrasonic diffusers, nebulizers and CPAP machines are safe and effective for administering a variety of active ingredients. These devices use vaporized water to deliver ingredients including essential oils for aromatherapy, steroids for asthma and breathing treatments for infant croup.
A nebulizer (ultrasonic vaporizer) is a delivery device used to administer medication in the form of a mist
inhaled into the lungs. Nebulizers are commonly used for the treatment of cystic fibrosis , asthma , COPD
and other respiratory diseases or disorders.
erj.ersjournals.com/content/18/1/228Nebulizers break up suspensions into small aerosol droplets that can be directly inhaled. This is the exact
same process as when a personal vaporizer uses a heated coil (at the proper temperature) to break up
aerosol droplets and deliver nicotine, cannabis, and now botanicals via Inhalation.
Composition of Ingredients During Vaping Vaporization does not heat the active ingredients in a formula to a level that would cause a chemical
composition change. The molecular structure of the botanical is not altered when administered via
vaporization nor is it altered during ingestion.
Therefore, the structure absorbed into the bloodstream is exactly the same whether it is contained in
liquid (ingestion) or steam (vaporization). “Intramolecular forces (bonding forces) exist within molecules and influence the chemical properties.
Intermolecular forces exist between molecules and influence the physical properties. We can think of H20
in its three forms, ice, water and steam. In all three cases, the bond angles are the same, the dipole
moment is the same, the molecular shape is the same and the hybridization of the oxygen is the same.
However, the physical properties of H20 are very different in the three states.”
www.khanacademy.org/test-prep/mcat/chemical-processes/covalent-bonds/a/intramolecular-and-intermolecular-forces
So, vaporization atomizes the active ingredients without changing their molecular composition. These
ingredients are suspended in water droplets the same way they are carried during ingestion. They do not
change form and are passed into the bloodstream exactly as they would be if delivered via ingestion or
diffusion.
That allows us to draw a correlation between the safety and efficacy of herbal extracts that are used via
ingestion or diffusion and the safety and efficacy of the herbal supplements delivered through
vaporization.
InhalationThe average efficacy of substances inhaled is 2-3X the efficacy of ingestion. Substances taken orally must pass through the stomach and go through the process of digestion before they can be absorbed into the bloodstream. Therefore, extracts that are directly inhaled (vaporized) are 2-3X more effective than when ingested. Ingestion is both unreliable and inconsistent. Inhalation is a consistent, reliable, and nearly instantaneous method of administering a variety of active ingredients.
According to the scholarly article The Lungs as a Portal of Entry for Systemic Drug Delivery , “inhaled
(medicines) have been used for over 50 years to treat airway disease and are in development or being
considered for the treatment of many other lung diseases…
A number of companies are in advanced clinical trials with inhaled insulin, and a variety of large and small
molecules are under investigation as inhaled formulations for systemic applications. For thousands of
years humans have inhaled a variety of substances for systemic effect (primarily as smoke), and now the
medical establishment is starting to realize the significant potential of this route of delivery.”
www.atsjournals.org/doi/full/10.1513/pats.200409-049TAAlterna™ MIXOLOGYNew formulas can easily be created from existing 0mg eLiquids. Slight changes may be required to
account for the concentration of the extract blend. Alterna has a pleasant, natural sweetener flavor that
can offset your need for sweetener in your formulas.
Formula 15
We prefer the effect of adding 15% Alterna to an existing 0mg flavor formula then adjust concentration up
or down to control effect.
Alterna blends well with formulas using mainstream flavor profiles - typically Capella - and will provide a
slight natural sweetness to your blends. It is not intended to compete with your flavor profile but some
mixologists may prefer to account for Alterna as a flavor component of a formula.
Typical feedback is that Alterna has a far more pleasurable effect on flavor than nicotine. Multiple users
have commented that the lack of a strong “throat hit” has allowed them to vape consistently without
negative side effects.
ConcentrationsDRIP
15% - Similar to a 3mg in terms of stimulant effect, mood support, appetite control and detox
TANK
15% - Similar to 4mg in terms of stimulant effect...
20% - Similar to 6mg in terms of stimulant effect...
CLOSED
25% - Higher concentration to account for lower absorption
DevicesAlterna-based vLiquids can be used in Diffusers, humidifiers and Vaporizers.
Retail Price PointVaporization liquids featuring Alterna will be priced similarly to existing nicotine liquids and maintain that
price point without having to account for PMTA costs or additional “sin” taxes.
Use Cases and Testimonials
1. Help you move away from nicotine
2. Help you continue to enjoy vaping
KAREN
After three days of vaping her favorite eLiquid with Alterna™ instead of nicotine, Karen's husband let her
know that she had been vaping a non-nicotine eLiquid and broken her addiction to nicotine.
WILLIAM
William had been vaping 3mg nicotine heavily for two years and had been a frequent smoker prior to
using vaping to quit. After two years he decided to kick the nicotine habit using Alterna. After about a week of vaping Alterna he tried 3mg again and felt sick from the effect. He jumped back onto Alterna and
has not looked back.
AARON
A heavy 3mg all day vaper, Aaron has cut his nicotine consumption in half by mixing in Alterna eLiquids.
Market TestElixir Distribution has provided tens of thousands of bottles of botanically infused Elixirs containing Green
Tea, Mate, St John’s Wort, Valerian, Ginseng, Peppermint and Kava in our widely available Epothecary and Speakeasy Elixirs.
For the more than three years that we have been on the market, we’ve had no complaints of adverse
reactions from vaporizing these botanicals. We hear daily about the beneficial effects of our products and
have a large community of followers who provide us with amazing testimonials. Please see our feed on
Instagram | @elixirvapeco
APPENDIXDescriptions of Botanicals
YERBA MATEYerba mate has been used as a base for herbal medicines for centuries, and the plant’s benefits and
therapeutic properties have recently been verified by scientific studies.
Yerba Mate helps stimulate focus and clarity, boosts energy and is traditionally used to support weight loss programs that include a balanced diet and exercise.
Yerba mate contains vitamins A, C, E, B1, B2, Niacin (B3), B5, B Complex. It also contains minerals such as Calcium, Manganese, Iron, Potassium, Magnesium and Zinc. Additional Compounds include Carotene, Fatty Acids, Antioxidants and 15 Amino Acids.
www.ncbi.nlm.nih.gov/pmc/articles/PMC4344557/GREEN TEAGreen tea is used by many to improve mental alertness and acuity. It’s a known source of physical energy. Studies have found that green tea is helpful in preventing stress and chronic fatigue, improving skin and reducing inflammation.
Natural chemicals – polyphenols – are thought to provide anti-inflammatory and anti-carcinogenic effects.
Green tea is a great source of antioxidants and it encourages weight loss. In many places it is used to treat stomach disorders, vomiting, and headaches.
www.ncbi.nlm.nih.gov/pmc/articles/PMC2855614/BURDOCKBurdock root has been valued across continents for thousands of years for its ability to purify blood and
cool internal heat. Internally and externally, it has potent anti-inflammatory and antibacterial effects on
the human body.
Recent studies also show that burdock contains phenolic acids, quercetin and luteolin, which are all powerful, health-promoting antioxidants.
Learn more in this University of Michigan study:
www.uofmhealth.org/health-library/hn-2057006#hn-2057006-how-it-worksPASSION FLOWERPassion flower is best known for its relaxing and calming effects. Multiple human and animal studies have
confirmed it’s effective at supporting a balanced mood without harmful side effects. Studies have found
that while prescription medications work faster, they also produce problems, including dizziness and
job-related impairment. Passion flower is far more gentle.
Combining passion flower with other calming herbs can increase its potency. A randomized,
placebo-controlled study revealed that a combination of passion flower, valerian, and St. John’s wort had
positive effects on mood without causing cognitive impairment.
www.ncbi.nlm.nih.gov/pubmed/11679026ST JOHN’S WORTSignificant scientific evidence shows that St. John’s Wort is helpful in treating mild depression, and its’
benefits are similar to that of MAOIs. Millions of people use St. John’s Wort as a natural herbal alternative
for elevating mood and reducing anxiety. Studies from reputable research centers report that St. John's wort is more effective than a placebo and equally effective as tricyclic antidepressant drugs in the short-term (1 to 3 months) treatment of mild-to-moderate major depression. Experts continue to debate whether St. John's wort is as effective as SSRIs (selective serotonin reuptake inhibitors).
www.medicalnewstoday.com/articles/174928.php
